As introduced above, the novel protein SHPRH-146aa, which was encoded by the circ-SHPRH, regulates glioblastoma tumorigenicity via stabilizing the full-length SHPRH (SNF2 histone linker PHD RING helicase) protein by inhibiting its ubiquitin-mediated degradation (Begum et al., 2018; Wu et al., 2020). Here, SHPRH is linked to glioblastoma.