Della Peruta et al. reported how the tyrosine phosphorylation of BCR-ABL1, CRKL and STAT5 were decreased in PTPRG-transfected K562 and reported downregulation of PTPRG mRNA and protein in CML patients (Della Peruta et al., 2010). The gene discussed is PTPRG; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.