(Yamaguchi et al., 2020) manifested that D1R signaling played a pathogenic effect on the process of HF, and explained the association between the activation of D1R and increased risk of patients with HF, using a mouse model of pressure overload-induced HF and single-cell resolution analysis, which aimed to uncover gene expression changes in murine models and human patients at the early and the late stages of HF. The gene discussed is DRD1; the disease is hydrops fetalis.