In the present study, in order to clarify the cell heterogeneity between ischemic HF and non-ischemic HF, we integrated two scRNA-seq datasets of 1,324 and 1,480 cells from the left ventricles and gene expression profiles of 14 NF, 37 DCM, and 13 ICM samples to identify HF-related cell types and key regulators. The gene discussed is NFASC; the disease is familial dilated cardiomyopathy.