At present, NT-proBNP is relevant to various neonatal diseases, such as pulmonary hypertension (6, 7), PDA (8–14), valular diseases (15), respiratory distress syndrome (16), bronchopulmonary dysplasia (BPD) (7, 17, 18), and retinopathy of prematurity (19, 20). The gene discussed is NPPB; the disease is Patent ductus arteriosus.