G6PD and hyperinsulinemic hypoglycemia, familial, 4: Likewise, G6PD knockdown increased the susceptibility to HCoV 229E infection (Wu et al., 2008), suggesting a correlation between G6PD deficiency and susceptibility to SARS-CoV-2 infection (Buinitskaya et al., 2020; Jain et al., 2020; Vick, 2020).