CCL2 and neoplasm: By recruiting heterogeneous nuclear ribonucleoprotein L to the chemokine CCL2 promoter, lymph node metastasis-associated transcript 1 (LNMAT1) activates the CCL2 upregulation, recruits macrophages to the tumor, and promotes lymphatic metastasis via vascular endothelial growth factor C (VEGF-C) excretion (19).