CDX2 and neoplasm: Several clinicopathological and molecular features has been associated with a prognostic and/or predictive value in RC such us the mucinous histology (21, 22), the unresponsiveness associated with mismatch repair-deficient tumors (23), loss of CDX2 expression (24), elevated pretreatment CEA levels (25), high serum inflammation markers (26, 27), and the association between a low CD3 and CD8 tumor-infiltrating lymphocytes density in the pretreatment biopsies and minimal regression to CRT (28).