Based on data acquired from a 243-patientcohort collected by the cancer genome atlas (22) the highest percentage of mutations causing p53 inactivation in human papilloma virus (HPV) negative HNSCC occurs in TP53 itself (84%) followed by CDKN2A (57%) which either contains a homozygous deletion or a mutation (22). This evidence concerns the gene TP53 and head and neck squamous cell carcinoma.