Re-expression of cDOPEY2 decreases the expression of the anti-apoptotic protein Mcl-1 and substantially strengthens the cell lethality of CDDP by augmenting the apoptotic process in CDDP-resistant esophageal squamous cell carcinoma (ESCC) cells (29). Here, MCL1 is linked to esophageal squamous cell carcinoma.