For example, circAMOTL1 can significantly modulate the expression of the Protein Kinase B (AKT) as well as AKT-related pro-apoptotic (BAX and BAK) factors and anti-apoptotic (BCL-2) proteins, thus mediating the paclitaxel (PTX)-resistant effects in breast cancer (26). The gene discussed is AKT1; the disease is breast cancer.