Additionally, circFGFR1 promotes immune evasion of NSCLC cells and enhances tolerance to anti- PD-1- based therapy by interacting with miR-381-3p and upregulating the expression of C-X-C motif chemokine receptor 4 (CXCR4) (38). This evidence concerns the gene CXCR4 and non-small cell lung carcinoma.