explored the combined effects of cancer stem cells (CSCs), circRNA (hsa_circ_0003222), and immune checkpoint blockers in NSCLC malignant behavior as well as drug resistance and found that NSCLC resistance to anti-PD-L1-based therapy could be reduced by silencing hsa_circ_0003222 (37). The gene discussed is CD274; the disease is non-small cell lung carcinoma.