In contrast, high levels of [18F]FDG uptake by cancers cells, corresponding with upregulated expression of glycolysis-related genes, was correlated with reduced numbers of CD8+ T-cells, increased T-cell exhaustion gene signatures and higher levels of PD-L1 in NSCLC by others (126), which potentially can stratify patients for subsequent immune checkpoint inhibition. The gene discussed is CD274; the disease is non-small cell lung carcinoma.