Well-studied signaling pathways, including PI3K/Akt/mTOR and RAS/RAF/MEK/MAPK, with high prevalence in lung cancer, associate with increased glycolysis as well as metabolic plasticity, by initiating compensatory mechanisms and facilitating alternative metabolic sources, e.g., amino acids, nucleotides or fatty acid biosynthesis and macropinocytosis. This evidence concerns the gene AKT1 and lung cancer.