First, MM patients have very complicated genomic and epigenetic backgrounds, for example, MM patients with t(4;14) translocations harboring high level of a histone methyltransferase, NSD2, which catalyzes histone dimethylation at lysine 36 (H3K63me2) (28), and these aberrations play a crucial role in MM roles in MM pathogenesis. Here, PRDM9 is linked to Miyoshi myopathy.