MiR-186 targets and negatively regulates METTL3 expression and inhibits the activation of Wnt/β-catenin signaling pathway, thereby inhibiting the proliferation and invasion of HB cells (72); In HBV-associated HCC, HBx protein encoded by HBV x gene upregulates METTL3 expression. Here, METTL3 is linked to hepatocellular carcinoma.