On the contrary, YTHDF3 reversibly and selectively binds to the m6A modified GAS5 to trigger the decay of GAS5, thus promoting the progress of CRC and forming a negative feedback loop (79); In colorectal cancer, lncRNA LINRIS (Long Intergene Non-Coding RNA For IGF2BP2 Stability) is highly expressed. This evidence concerns the gene GAS5 and colorectal carcinoma.