MiR-25-3p targets to inhibit the expression of tumor suppressor PHLPP2, thereby activating AKT-p70S6K oncogene signal and promoting the start and development of pancreatic ductal adenocarcinoma (PDAC) (100); ALKBH5 is down-regulated in pancreatic cancer tissues. Here, ALKBH5 is linked to familial pancreatic carcinoma.