Through a comprehensive analysis of lncRNAs m6A modification in CRC, it was found that the methylation level of lncRNAs in CRC tissues was significantly higher than that in adjacent normal tissues (109); METTL14 promotes the m6A modification of the carcinogen lncRNA XIST, which makes XIST degrade in a YTHDF2-mediated manner, thereby inhibiting the proliferation and invasion of CRC cells (76); Similarly, METTL14 also acts on the tumor suppressor microRNA miR-375 and promotes the processing and maturation of miR-375. The gene discussed is YTHDF2; the disease is colorectal carcinoma.