The high expression of GNAS promotes the activation of STAT3 in LPS-induced HCC cells by inhibiting the interaction between the lncRNA TPTEP1 and STAT3, and ultimately led to the growth and invasion of LPS-induced HCC cells (97); The expression of circRNA circ_KIAA1429 is up-regulated in HCC. This evidence concerns the gene TPTEP1 and hepatocellular carcinoma.