Finally, METTL14 inhibits the growth of CRC cells through the miR-375/YAP1 pathway and inhibits the migration and invasion of CRC cells through the miR-375/SP1 pathway (77); Epithelial-mesenchymal transition (EMT) is the first and most important step in cancer cell metastasis (110). The gene discussed is SP1; the disease is colorectal carcinoma.