LINRIS blocks the degradation of Reader IGF2BP2 through the ubiquitination-autophagy pathway, thereby maintaining the stability of MYC mRNA (MYC mRNA is a typical target of IGF2BP2 and one of the core regulators of glycolysis) and promotes MYC-mediated Glycolysis and proliferation of colorectal cancer cells. The gene discussed is MYC; the disease is colorectal cancer.