ALKBH5 and malignant colon neoplasm: Moreover, ALKBH5 or NEAT1 gene knockout can partially inhibit the malignant behavior of colon cancer (78); CircNSUN2 is often upregulated in patients with liver metastasis (LM) from colorectal cancer and is exported from nucleus to cytoplasm in an m6A-dependent manner through binding to YTHDC1.