As shown in Figure 4B, +12 CLL cells were characterized by maintenance of stable levels of Notch2 and Mcl-1 during treatment with venetoclax (n = 9 for Notch2 and n = 6 for Mcl-1, *p < 0.05, **p < 0.01). This evidence concerns the gene MCL1 and B-cell chronic lymphocytic leukemia.