To investigate the correlation between serum CRP and in situ immune infiltration in HCC, we performed immuno-histochemistry to assess the distribution of CD11b+ myeloid cells, CD68+ TAMs, CD15+ TANs and CD8+ T cells in the nontumor (NT) and intratumor (IT) regions of HCC tissues. This evidence concerns the gene CD8A and hepatocellular carcinoma.