The results of the subgroup analysis were consistent with the results of the whole population, except for not first-line treatment, which may have been confounded by malnutrition or poor quality of life in long-term survival.<h4>Conclusion</h4>The efficacy of anti-EGFR targeted therapy was positively associated with the hypokalemia incidence rate. The gene discussed is EGFR; the disease is Hypokalemia.