Over long-term follow-up (24-52 weeks), MCO dialysishad a trivial to no effect on serum albumin levels with MD −0.02 g/dl (95%CI, −0.07 to −0.03; I2 = 56%; high certainty).No studies reported hypoalbuminemia that required albumin infusion ordiscontinuation of treatment with MCO membranes. This evidence concerns the gene ALB and Hypoalbuminemia.