AGT and hypertensive disorder: Like the sensitizing effect of HEM on Ang II-induced hypertension, treatment with TM in S-HEM rats also sensitized the hypertensive response to systemic Ang II (Δ45.6 ± 4.4 mmHg) when compared to that in S-HEM alone (Δ26.9 ± 1.9 mmHg, p < 0.05, Figures 2(a) and 2(b)).