ACE2 and hypertensive disorder: However, treatment with either the ACE1 inhibitor Cap or the ACE2 activator DIZE abolished the HEM-induced sensitization of hypertension in the HEM rats (Cap, Δ19.4 ± 3.1 mmHg; DIZE, Δ25.1 ± 2.2 mmHg, p < 0.05, Figures 1(a) and 1(b)) (two-way ANOVA for changes in MAP, F(3, 15) = 19.72, p < 0.001).