SPP1 and neoplasm: Then, we picked out 8 HAIRGs (VEGFA, CTNNB1, PPARG, HSP90AA1, HMOX1, LGALS3, SPP1, and RAC1) from the 17 HAIRG model through the LASSO Cox regression, upregulated genes accounted for 7/8 in tumor tissue, which was shown by a heat map (Figure 1(c)).