IGF1 and hepatocellular carcinoma: Univariate Cox regression analysis showed 17 HAIRGs (VEGFA, MMP9, TGFB1, MAPK1, SRC, CTNNB1, SPP1, PPARG, HMOX1, RAC1, IGF1, HSP90AA1, BRAF, RELA, LGALS1, CASP8, and LGALS3) were significantly related to the OS for HCC patients, sixteen of which were high hazard ratio genes (HR > 1) and one was protective genes (HR < 1) (Figure 1(b)).