HK2 and nonpapillary renal cell carcinoma: It has been recently reported that LncRNA THOR directly binds to IGFBP-1 to induce ATP production and increase the transcription levels of HK2, phosphoinositol dependent protein kinase 1 and the transcription level of Myc 56, and regulates the genetic stability of key oncogenes, while promoting ccRCC proliferation.