Xu CL et al.found the potential role of acyl-coa thiesterase (ACOT8) in oxidative phosphorylation regulation of ccRCC, in which ACOTs was significantly down-regulated and showed that ACOT8 upregulated the expression of iron death suppressor genes, such as glutathione peroxidase 4(GPX4) 29. This evidence concerns the gene GPX4 and nonpapillary renal cell carcinoma.