SIRT1 and nonpapillary renal cell carcinoma: Recent studies, for the first time, demonstrated that aberrant 6PGD expression is closely associated with ccRCC carcinogenesis, chemotherapy and immune resistance, revealing that 6PGD downregulation would activate AMPK signaling, leading to acetyl-CoA carboxylase 1 (ACC1) inhibition and reduced lipid synthesis, disrupting NADPH and NADH in ccRCC cells homeostasis in vivo and inhibits SIRT-1 activity, sensitizing ccRCC cells to general anticancer drugs 89.