CYCS and nonpapillary renal cell carcinoma: And Gong A et al. found that IncRNA MEG3 mediates ST3Gal1 to regulate EGFR phosphorylation, which will downregulate Bcl-2 and prcaspase-2 expression,upregulate caspase-2 and cytochrome c release69 , leading to mitochondrial dysfunction and inducing apoptosis in ccRCC cells.