YANG et al. found that KCNQ1DN was significantly reduced in ccRCC tissues and cell lines, and gene analysis showed that KCNQ1DN could affect downstream coding genes, such as GLUTs and HK2, by inhibiting the transcriptional activity of c-MyC gene promoters, thus obstructing glucose intake, inhibiting glycolysis pathway and reducing energy supply 49. The gene discussed is HK2; the disease is nonpapillary renal cell carcinoma.