Tello D et al. showed that NDUFA4L2 is highly upregulated in ccRCC tissues, controlling mitochondrial growth while counteracting the excessive production of ROS due to mitochondrial respiratory chain damage in ccRCC cells, and It increases the level of cellular antioxidant and makes ccRCC cells stronger and more aggressive 64. The gene discussed is COXFA4L2; the disease is nonpapillary renal cell carcinoma.