BCL2 and nonpapillary renal cell carcinoma: Zhao Y, et al. suggested that MET upregulates the expression levels of pro-apoptotic proteins such as Bax, Bak, caspase-3 and caspase-9 and downregulates the expression levels of Bcl-2 by activating reactive oxygen species, targeting the mitochondria-dependent apoptotic pathway and inducing DNA6 breakage which in turn affects ccRCC cell growth 88.