YANG et al. found that KCNQ1DN was significantly reduced in ccRCC tissues and cell lines, and gene analysis showed that KCNQ1DN could affect downstream coding genes, such as GLUTs and HK2, by inhibiting the transcriptional activity of c-MyC gene promoters, thus obstructing glucose intake, inhibiting glycolysis pathway and reducing energy supply 49. Here, KCNQ1DN is linked to nonpapillary renal cell carcinoma.