E2F2 and colorectal carcinoma: In CRC patients with down-regulated E2F2 expression, the survival rates were also lower in stages N1 +N2, including OS (HR = 0.49, 95% CI = 0.29-0.83, p = 0.009, Supplememtary Figure S2D), PFI (HR = 0.59, 95% CI = 0.37-0.95, p = 0.028, Supplememtary Figure S2E) and DSS (HR = 0.47, 95% CI = 0.25-0.89, p = 0.02, Supplememtary Figure S2F).