E2F2 and colorectal carcinoma: In addition, ROC analysis of different subgroups of CRC patients elucidated that E2F2 expression lent a degree of credibility to distinguish early and advanced stage patients, including (T1-2) vs. (T3-4) stage (AUC = 0.538, 95% CI: 0.486-0.591, Supplementary Figure S3A), N0 vs. (N1-2) stage (AUC = 0.576, 95% CI: 0.531-0.621, Supplementary Figure S3B), M0 vs. M1 (AUC = 0.607, 95% CI: 0.543-0.671, Supplementary Figure S3C), pathology stage (I-II) vs. (III-IV) (AUC = 0.571, 95% CI: 0.526-0.617, Supplementary Figure S3D).