As shown in Figure 5 and Table 4, several signal pathways were significantly enriched in high E2F2 expression group, including ATR pathway (Figure 5A), ATM signalling pathway (Figure 5B), mismatch repair (Figure 5C), base excision repair (Figure 5D), homologous recomibination (Figure 5E) and Fanconi Anemia pathway (Figure 5F). This evidence concerns the gene ATM and Fanconi anemia.