Moreover, GINS2 co-expressed and cell cycle-related genes, such as CDK1, CDC25A, CDC45, MCM3, CDC25C and MCM2, were also shown positive correlation with the abundance of infiltrating B cells, CD8+ T cells, CD4+ T cells, macrophages, neutrophils and DCs in HCC (Figure 4B-G). The gene discussed is CDC45; the disease is hepatocellular carcinoma.