CDC45 and digestive system neoplasm: Furthermore, CDK1, which acts as a key factor in the process of the eukaryotic cell cycle by regulating the centrosome cycle and mitotic onset; CDC25A, which takes effect by inducing mitotic progression; and other genes related to the cell cycle (e.g., CDC45, MCM3 and CDC25C) and DNA replication (e.g., CDT1, CHAF1A, and FEN1) were positively correlated with the expression of GINS2 (Figure 3C, Figure S4B), which further implied the significant role of GINS2 in liver carcinogenesis and tumor progression.