For instance, ERCC3 rs4150434 and ERCC5 rs4771436 and rs2094258 SNPs were previously associated with genetic susceptibility to lung cancer 31, ERCC5 rs2296147 was associated with a reduced risk of esophageal cancer 32, and ERCC2 rs1799793 was positively associated with prostate cancer risk in an Asian population 16. This evidence concerns the gene ERCC3 and Familial prostate cancer.