Using stratified analysis, we showed that the ERCC5 rs4771436 GG genotype, the recessive model (GG vs. GT+TT) and ERCC5 rs1047768 CC genotype, the recessive model (CC vs. CT+TT) conferred 5.01-fold, 5.39-fold, 3.06-fold, and 3.25-fold increases in lung cancer progression, respectively, in patients aged ≤60 years. Here, ERCC5 is linked to lung carcinoma.