ERCC2 and Familial prostate cancer: For instance, ERCC3 rs4150434 and ERCC5 rs4771436 and rs2094258 SNPs were previously associated with genetic susceptibility to lung cancer 31, ERCC5 rs2296147 was associated with a reduced risk of esophageal cancer 32, and ERCC2 rs1799793 was positively associated with prostate cancer risk in an Asian population 16.