Oxnard et al. 75 reported that combination of durvalumab and osimertinib (a third generation of EGFR tyrosine kinase inhibitor) would increase the morbidity of interstitial lung disease (38%) in NSCLC patients with mEGFR (L858R or exon19 insertion/deletion), while significant clinical benefits were not observed. This evidence concerns the gene EGFR and non-small cell lung carcinoma.