HER-2 is mainly found in ECCA, Nam 57 found that through preclinical experiments on CCA cells and mouse models, the drug named trastuzumab for this target showed a good anti-tumor effect, indicating that HER-2 may be a potential target of HER-2 gene inhibitors is slightly better in patients with gallbladder cancer. Here, ERBB2 is linked to gallbladder cancer.