As shown in Table 2, univariate and multivariate analyses of risk factors for HCC patients with BM showed that there was no significant difference in gender, age, ABO blood type, smoking history, family history of cancer, antiviral history, vascular tumor thrombus, intrahepatic metastasis, extraosseous metastases, serum AFP, HBsAg, WBC and PLT level between BM patients and non-BM patients. The gene discussed is AFP; the disease is vascular neoplasm.