Thereafter, several various assays were performed to examine cell death, proliferation, senescence, chemoresistance, invasion, polyploid giant cancer cells (PGCCs) formation, self-aggregation, and secretion of an angiogenic factor VEGF (vascular endothelial growth factor), in the si-ARID1A-transfected cells compared with those transfected with siControl. This evidence concerns the gene ARID1A and cancer.