A mechanism study showed that the antiapoptotic effect induced by FGF21 in type 1 diabetes mellitus (T1DM) mice was attributed to the activation of AMPK, followed by the inactivation of phosphatase and tensin homolog (PTEN), which negatively regulates Akt signaling [9, 27, 28]. Here, AKT1 is linked to type 1 diabetes mellitus.