In VISION, a multicohort, open-label, phase 2 study, 152 patients affected by advanced NSCLC not-oncogene addicted with MET 14 exon-skipping mutations, have received tepotinib, a high selective oral MEK-inhibitor, at a dose of 500 mg once daily, in order to evaluate its efficacy and side-effect profile. This evidence concerns the gene MET and non-small cell lung carcinoma.