In ACC (r = −0.43, p < 0.05), BLCA (r = −0.22, p < 0.05), BRCA (r = −0.12, p < 0.05), CESC (r = −0.26, p < 0.05), ESCA (r = −0.35, p < 0.05), GBM (r = −0.3, p < 0.05), HNSC (r = −0.26, p < 0.05), LUAD (r = −0.18, p < 0.05), LUSC (r = −0.28, p < 0.05), OV (r = −0.21, p < 0.05), PRAD (r = −0.23, p < 0.05), TGCT (r = −0.29, p < 0.05), THCA (r = −0.31, p < 0.05), and UCEC (r = −0.18, p < 0.05), immune score was negatively correlated with SRSF9 expression and the highest correlation coefficient was in ACC. Here, SRSF9 is linked to adrenal cortex carcinoma.