Moreover, the receptor LGR4 that was reported to mediate Wnt signalling in DS cells (Hagner et al., 2020), was significantly enriched in the young DS population (p < 0.0001, FindAllMarkers function with implemented Wilcoxon Rank Sum test) (Supplementary Figure S5, Supplementary Table S2). This evidence concerns the gene LGR4 and Dravet syndrome.