CD4 and neoplasm: Moreover, higher infiltration scores of T cells, especially activated CD4+ memory T cells, CD8+ T cells and follicular helper T cells, which have been regarded as the major immune cells for anti-tumor efficacy (Biase et al., 20192019), were demonstrated in the ICI cluster C and this subtype also presented longer median survival time than other two clusters through Kaplan-Meier survival analysis (Figure 1C,E).