In previous studies, the VDR BsmI B allele increased the risk of osteoporotic fracture (OR 1.17, 95% CI 1.03–1.34), and the bb genotype reduced the risk of osteoporotic fracture in the United States (additive model: OR 0.74, 95% CI 0.88–0.94; allelic model: OR 0.81, 95% CI 0.66–0.99), but after excluding low-quality and HWD studies, the results showed no significant association between VDR BsmI gene polymorphism and fracture risk in the American population (allelic model: OR 1.18, 95% CI 0.82–1.70; additive model: OR 0.73, 95% CI 0.38–1.40; recessive model: OR 0.91, 95% CI 0.59–1.42). Here, VDR is linked to bone fracture.