VDR and osteoporosis: Finally, the Hardy–Weinberg equilibrium (HWE) test was not performed in the three studies (Moher et al., 2009; Shen et al., 2014; Gao et al., 2015), and not all studies on the VDR polymorphisms with osteoporosis fracture risk adjusted the P-value (Aerssens et al., 2000; Moher et al., 2009; Shen et al., 2014; Gao et al., 2015).