Cyclin-dependent kinase 5 (CDK5) is a serine/threonine protein kinase that contributes to the glucose-dependent regulation of insulin secretion (Li et al., 2020); therefore, it plays a critical role in the pathophysiology of β-cell dysfunction and predisposition to T2DM (Li et al., 2020; Wei et al., 2005; Ubeda et al., 2006). The gene discussed is INS; the disease is type 2 diabetes mellitus.