The Kaplan-Meier plot indicated that high expression of CASP3, CASP4, CASP5, CASP6, CASP8, ELANE, GSMAD, IL6, NLRP3, NOD1, NOD2, PLCG1, PRKACA, PYCARD, and SCAF11 was associated with poorer OS in glioma. This evidence concerns the gene NOD2 and central nervous system cancer.