NLRP2, NLRP7, and PLCG1 were the only gene alterations in LGG, and NLRP3, NLRP7, NLRP2, SCAF11, NOD1, PLCG1, NLRP1, and CASP1 were gene alterations in GBM. The gene discussed is PLCG1; the disease is glioblastoma.