In addition, also chemotherapy- or radiotherapy-based apoptosis of tumor cells, and also providing various danger signals (e.g., ATP, UTP, calreticulin, HMGB1) that activate DCs and can strengthen T cell priming and memory (immunogenic cell death) (66), enable tumor cells to unveil non-mutated neoantigens, in the form of caspase-cleaved antigenic fragments (67). This evidence concerns the gene HMGB1 and neoplasm.