Several studies (86–89) of liver tumor model rats and mice (86–89) and dogs (90) showed an increased density of localized CD3+ T cells (90), CD8+ T cells (86, 87, 89), dendritic cells (DCs) (86), and macrophages (88) and a decreased number of Treg cells (86, 87) and PD-1+ T cells (86) in the tumor tissue after IRE treatment. The gene discussed is CD8A; the disease is neoplasm.