In conclusion, with the help of WGCNA and LASSO combined with bioinformatic analysis using ssGSEA, one hub module (black module) and five hub genes (CYP3A5, SLC12A3, BGN, TAPBP and TMEM184B) that might be involved in the progression of ANCA-GN were screened. The gene discussed is CYP3A5; the disease is ganglioneuroma.