Blocking of the TF AP-1 by the synthetic retinoid SR11302 also inhibited Th1/Th17 proliferation and enhanced Treg expansion by indirectly pSTAT3 blockage and STAT5 dependent FoxP3 expression, leading to diminished GVHD-associated pathology and lethality (191). This evidence concerns the gene FOXP3 and graft versus host disease.