In animal models used in experimentation, Hunsche et al. (5) observed that macrophage and lymphocyte chemotaxis, macrophage phagocytosis, NK cell activity, lymphocyte proliferative response, secretion of IL-1β, TNF-α, IL-6, IL-2 and IL- 10 in leukocyte cultures, as well as the antioxidant and oxidative capacity of obese adult rats were significantly impaired when compared to non-obese adult rats and similar to elderly rats, thus concluding that obesity can generate premature immunosenescence that is aggravated as the obese adult rat ages. Here, IL1B is linked to obesity due to melanocortin 4 receptor deficiency.