Several studies have shown that the dysfunction in adipose tissue resulting from obesity leads to a chronic inflammatory state firstly in all of the adipose tissue but becoming systemic through the release of pro-inflammatory adipokines and cytokines such as Leptin, TNF-α, IL-6, IL-8, CRP, MCP1, among others in the peripheral blood circulation (6–8, 34). Here, LEP is linked to obesity due to melanocortin 4 receptor deficiency.