And whether m6A “reader” (signal converter_YTHDF1, YTHDF2), “eraser” (demethylase_FTO, ALKBH5), etc. or how to convert can increase the sensitivity of colorectal cancer patients to immune checkpoint therapy and reduce the resistance of colorectal cancer patients to anti-PD-1/PD-L1 therapy still needs further research. The gene discussed is ALKBH5; the disease is colorectal cancer.