In a randomized controlled trial in patients with PD-L1+ NSCLC the combination of in vitro expanded allogenic NK cells with anti-PD-1 improved overall survival (OS) and progression-free survival (PFS), compared to single anti-PD-1 treatment, without adverse events associated with NK cell therapy [NCT02843204 (27)]. This evidence concerns the gene CD274 and non-small cell lung carcinoma.