LAG3 and non-small cell lung carcinoma: LAG-3 direct targeting is exploited by the use of a soluble dimeric recombinant LAG-3 (Eftilagimod alpha or IMP321), that stimulates DC through MHC class II molecules and induces sustained immune responses together with anti-PD-1, in patients with previously untreated unresectable or metastatic NSCLC (NCT03625323).