T cell immunoglobulin and mucin domain protein 3 (TIM-3), similarly to LAG-3, is an inhibitory receptor frequently detected upregulated on NSCLC TILs during tumor progression and is associated with an exhausted, burned phenotype of TILs and resistance to ICI (23, 24). The gene discussed is HAVCR2; the disease is non-small cell lung carcinoma.