Combination of epacadostat and pembrolizumab have largely disattended previous expectations in melanoma, and subsequently a phase II clinical trial investigating its potential activity in combination with pembrolizumab alone for treatment-naïve PD-L1 high (≥50%) NSCLC patients has been discontinued due to lack of advantage compared to pembrolizumab alone (NCT03322540). This evidence concerns the gene CD274 and melanoma.