BMAL1 in macrophages inhibited the production of ROS and HIF1α, and affected tumor growth through regulating macrophage alternative polarization (43) RORα and RORγ in T cells (Th17 cells and CD8+ T cells) could modulate their differentiation and activation, which affected tumor growth and the antitumor immune response (44–46). This evidence concerns the gene CD8A and neoplasm.