Dysregulated and constitutively active MyD88 signaling caused by the mutation L265P within its TIR domain is characteristic for distinct types of diffuse large B-cell lymphoma (e.g., Waldenström’s macroglobulinaemia, WM), where almost 90% of patients harbor L265P mutation (8, 9). This evidence concerns the gene MYD88 and diffuse large B-cell lymphoma.