Our results may explain the findings from studies of autoinflammatory disorders, such as familial cold autoinflammatory syndrome (FCAS), which is characterized by mutations in the NLRP3 gene that result in augmented caspase-1 activation and elevated production of IL-1β, leading to episodic arthralgia, rash, and fever in response to cold exposure. The gene discussed is NLRP3; the disease is familial cold autoinflammatory syndrome.