HLA-C and myeloid sarcoma: In conclusion, major hurdles in translating these into patients include the differences of immune mechanisms between rodents and humans, e.g. with respect to the complexity of the MHC/HLA, the fact that EAE is an induced model, while MS arises spontaneously and probably long time before it becomes clinically manifest, the complexity and heterogeneity of disease mechanisms that contribute to MS, the still incomplete knowledge about target antigens, and, as will be detailed below, the difficulties of demonstrating tolerance induction and the underlying mechanisms in humans.