There is solid evidence that certain immunodominant peptides of MBP, MOG, PLP and a few other non-myelin/non-CNS antigens appear involved in MS, and CD4+ T cells against are increased in MS, show higher antigen avidity, express proinflammatory phenotypes, and are frequently restricted by MS-associated HLA-DR molecules (4, 20–22, 26, 84). This evidence concerns the gene MBP and myeloid sarcoma.