Consistent with the fact that MS only affects the CNS and that demyelination is a key aspect of MS lesions, but also with data from EAE studies, autoreactive CD4+ T cells recognize peptides from several myelin proteins including myelin basic protein (MBP), proteolipid protein (PLP), myelin oligodendrocyte glycoprotein (MOG) and a few others [recently summarized in detail in (11, 21)]. This evidence concerns the gene OMG and myeloid sarcoma.