p300 (also known as KAT3B), a classic acetyltransferase that specifically acetylates histone H3K18 and H3K27 (30), also catalyses protein lactylation (29), and the study by Eskandarian et al. found H3K18 acetylation to be significantly reduced during bacterial and adenovirus infection through SIRT2 and CBP/p300 (31). Here, SIRT2 is linked to adenoviridae infectious disease.