Sepsis and septic shock had been associated with multiple biomarkers of inflammation, such as PCT (51, 52), CRP (53), Soluble CD14 subtype (54), and soluble urokinase-type plasminogen activator receptor(suPAR) (55), etc. However, there is no single golden standard diagnostic biomarker to differentiate septic shock patients from non-septic shock patients (2, 56). Here, CD14 is linked to septic shock.