MAP2K1 and neoplasm: Furthermore, in the multivariable Cox proportional hazards regression model adjusted by tumour stage, LDH, and MAP2K1/2 mutations, these three factors were still significantly associated with OS (HR = 0.24; 95% CI, 0.059–0.99; p = 0.048; Table 1) and PFS (HR = 0.39; 95% CI, 0.16–0.99; p = 0.048; Table 1).