For 55 significantly differentially expressed genes between MAP2K1/2-mutated and wild-type melanoma in clinical cohort, 14 genes (SMAD9, LRP6, PCDH18, TP53BP2, KDM1A, PKLR, GALNT5, RASGRF2, CTSK, ZNF845, ZNF384, TEK, MTHFD1, TAX1BP1) were associated with the immunological microenvironment as previous reports. The gene discussed is LRP6; the disease is melanoma.