For 55 significantly differentially expressed genes between MAP2K1/2-mutated and wild-type melanoma in clinical cohort, 14 genes (SMAD9, LRP6, PCDH18, TP53BP2, KDM1A, PKLR, GALNT5, RASGRF2, CTSK, ZNF845, ZNF384, TEK, MTHFD1, TAX1BP1) were associated with the immunological microenvironment as previous reports. Here, SMAD9 is linked to melanoma.