MAP2K1 and melanoma: Analysis results revealed that MAP2K1/2-mutated melanoma exhibited significantly increased densities of B cells (p = 0.015), CD8+ T cells (p = 0.024), and neutrophils (p = 0.03) and a numerically higher level of myeloid dendritic cells (p = 0.089) compared to those in their wild-type counterparts, implying that melanoma patients with MAP2K1/2 mutations have a favourable microenvironment for tumoral development (Figure 4A).