ITGAM and systemic sclerosis: We performed neutrophil activation experiments using a FcyRIIA blocking antibody (Clone IV.3) and found a significant decrease in neutrophil activation induced by SSc plasma containing high fMet levels (CD66b; p<0.0001 and CD11b; p=0.02) as well as low fMet levels (CD66b; p=0.0002 and CD11b; p=0.006) (Figures 6A, B).