Moreover, as shown in Figure 6F, the risk score was correlated with prognosis in univariate COX regression model (HR = 1.97, p = 0.004) in GSE14520 cohort, and the multivariate analysis suggested that the risk score was capable to independently predict the prognosis of HCC after adjusting for gender, age, AFP, ALT, tumor size, multinodular, BCLC staging, CLIP staging, and TNM staging (HR = 1.65, p = 0.038). The gene discussed is AFP; the disease is hepatocellular carcinoma.