High transcriptional levels of PHF19 were linked to unfavorable prognosis in OS of ACC, LIHC, MESO, and SKCM, and DFS analysis data showed that elevated PHF19 level was related to unfavorable prognosis for ACC, LGG, LIHC, and UVM (uveal melanoma) (all log-rank P values < 0.05). This evidence concerns the gene PHF19 and adrenal cortex carcinoma.