Moreover, we conducted the transcription factor target analysis, and found that DICER1 (dicer 1, ribonuclease III), GTF3A (general transcription factor IIIA), RUVBL2 (RuvB like AAA ATPase 2), and ZNF704 (zinc finger protein 704) were the main transcription factors participating in the PHF19-regulated pathways in HCC. The gene discussed is PHF19; the disease is hepatocellular carcinoma.