This strategy led to an optimal eleven-gene prognostic model in HCC, and the formula was applied to calculate the risk score of each patient, as follows: RiskScore = 0.081 ∗ KIF2C + 0.026 ∗ SMARCC1 – 0.005 ∗ ASF1B + 0.032 ∗ RBBP4 + 0.031 ∗ MCM6 – 0.012 ∗ KIF11 – 0.089 ∗ RAD54L + 0.069 ∗ GINS1 + 0.123 ∗ CBX8 + 0.001 ∗ ANP32B – 0.084 ∗ SUZ12. The gene discussed is CBX8; the disease is hepatocellular carcinoma.