COX regression analyses suggested that elevated PHF19 expression may lead to shorter OS and DSS in ACC, KICH, KIRC, LGG, LIHC, MESO, and PCPG, and Kaplan-Meier analyses revealed that high PHF19 expression predicted worse OS in BC, KIRC, KIRP, LIHC, LUAD, LUSC, and UCEC. Here, PHF19 is linked to breast cancer.