Among the top 6 hub targets of luteolin against COVID-19/asthma comorbidity predicted by the PPI network, the results showed that binding activity of luteolin with TNF was the best, and AKT1, ALB, TP53, IL-6, and VEGFA performed compact binding patterns with luteolin, but secondary to TNF. The gene discussed is AKT1; the disease is COVID-19.