It is well recognized that most Toll-like receptor signaling pathways share similar signal transduction pathways through MyD88-dependent pathways, which involve NF-κB and JAK/STAT signaling pathways to activate the production of various cytokines (IL-6, IL-1β, TNF-α, and so on), which is strongly associated with the progress of asthma and COVID-19 (108–111). The gene discussed is TNF; the disease is asthma.