ERN1 and infection: Furthermore, we found that the injection of the inhibitors of the endonuclease activity of IRE-1α, together with HSV-1 in the skin promoted both, Langerhans cell and dermal DC migration from the periphery to draining LNs after HSV-1 infection, suggesting that the presence of these drugs, at the site of infection with HSV-1, affects the capacity of Langerhans cells to migrate the LNs, allowing them to reach this tissue together with dermal DCs and thus, IRE-1α inhibition may help bypass to some extent the relay indicated above and favor HSV antigen presentation to T cells.